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According to Fanjul-Moles et al

This traceability emphasis is particularly relevant for enzyme inhibition studies where small changes in solvent composition, incubation time, temperature, or detection chemistry can produce differences that resemble potency shifts

Kunjiappan, S

The indirect effect occurs when the cell function is increased and there is an increased demand for glutathione, creating the situation of glutathione deficiency and a switch to TH2 function

Further to this, data from naturally aged, healthy wild-type mice provides supporting evidence by also showing an inverse relationship between serum B12 and IL- 6